药物代谢与药代动力学前沿、策略与应用Drug Metabolism and Pharmacokinetics Frontiers, Strategies and Applications 2025

基本信息
出版社:Wiley
出版日期:2025年 7月 9日
版本:1st
语言:英语
纸书页数:573页
ISBN-10:1394300123
ISBN-13:978-1394300129

内容简介
Practical, state-of-the-art pharmacokinetic research methods, ideas, advancements, applications, and strategies
Drawing on a wealth of extensive practical experience and theoretical research, Drug Metabolism and Pharmacokinetics encapsulates the most recent advancements and illustrative applications in the field. Sixty-eight relatively independent yet interconnected articles are included, each offering a unique perspective and providing in-depth interpretation. Readers can either read systematically or select specific topics of interest from the table of contents.
Basic concepts, frontier advancements, DMPK research strategies, and technical methods are covered for novel drug modalities and therapeutics in different disease areas. The book encompasses a wide range of application and validation cases for DMPK research, including studies in in vitro ADME, in vivo pharmacokinetics, metabolite profiling and identification, radiolabeled ADME, and bioanalysis. Case studies showing the application of topics covered are included throughout, along with valuable insights into problem-solving and critical thinking.
Written by a team of scientists specializing in DMPK research from the DMPK Department of WuXi AppTec, Drug Metabolism and Pharmacokinetics discusses sample topics including:
ADME properties, metabolite identification, and bioanalytical strategies for oligonucleotide drugs
Strategies and challenges in the determination of drug-to-antibody ratio (DAR) values of antibody-drug conjugates (ADCs)
Breaking barriers in CNS drug development with intrathecal and intracerebroventricular administration
Application and detection techniques of biomarkers in drug development
Flux dialysis method for assessing plasma protein binding of high protein-binding drugs
Drug Metabolism and Pharmacokinetics is an essential forward-thinking reference on the subject for pharmacy students, pharmaceutical industry researchers, and DMPK scientists, especially those exploring novel drug modalities.

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